Blog

AI-generated image of a white robotic hand against a blue-green background.

To automate or not to automate USP – what are the factors to consider?

Leave a Comment / Blog / By Kate Hannon

Within the bioprocessing industry it is often remarked that ‘the product is the process’; or rather, any change in the process, no matter how small, will impact the final product. Consequently, process consistency is seen as essential, and the automation of bioprocesses an appealing prospect as the industry matures. In particular, the automation of upstream …

To automate or not to automate USP – what are the factors to consider? Read More »

The Sticky Challenges of Bioprocessing

Leave a Comment / Blog / By Kate Hannon

Cell-to-cell adhesion of mammalian cells is what cells are supposed to do, but can be quite detrimental to bioprocessing, upstream and downstream, by producing cell clumps with later formation of larger clusters. Single cell suspensions, microcarrier-adherent cells and stem cell aggregates demonstrate this behaviour. How do we prevent something natural from occurring? The typical workaround …

The Sticky Challenges of Bioprocessing Read More »

Here’s why we are still “attached” to adherent cells

Leave a Comment / Blog, Insights / By Kate Hannon

Except for hematopoietic-derived cells, most cells isolated from animals are naturally adherent. In vivo, adherent cells interact with their surrounding environment and with each other in order to remain viable and exercise their specific function. Indeed, the intracellular signalling cascades that influence the cells’ morphology, growth, phenotype and final fate are governed by the cells’ …

Here’s why we are still “attached” to adherent cells Read More »

A black and white image of mouse myoblasts on day three of a batch growth run.

From Spinner Flasks to Stirred Tanks: Challenges and Solutions for Cell Culture Scale Up

Leave a Comment / Blog, Insights / By Kate Hannon

Multiple industries struggle to scale adherent cell culture for applications where the cells themselves are the target product. Traditional methods like T-flasks and multilayers, while useful in research settings, become limiting factors for large-scale production. Microcarrier-based cultures are a popular approach with many advantages, such as their high surface area per volume ratio, scalability, versatility, …

From Spinner Flasks to Stirred Tanks: Challenges and Solutions for Cell Culture Scale Up Read More »

The future of commercial-scale cell manufacturing

Leave a Comment / Blog, Featured / By Chris Green

Cell culture is at the cutting edge of biological innovation. However, the need to reach commercial scale presents many practical, scientific, regulatory, and ideological challenges. In CellRev’s new trend report, ‘The Future of Commercial-Scale Cell Manufacturing’, we highlight the challenges and opportunities in the field – compiling insights from our industry-wide survey and interviews with …

The future of commercial-scale cell manufacturing Read More »

Cell compatibility with CellRev technology

Leave a Comment / Blog / By Chris Green

At CellRev, we are working towards a bright future for adherent cell culture across industries such as cultured meat and seafood, cell and gene therapies, and broader cell expansion needs. While our compatibility continues to grow, here’s a closer look at some of the cell types we already work with and their major applications. Our …

Cell compatibility with CellRev technology Read More »

The rise of sustainable food production

Leave a Comment / Blog / By Chris Green

The global food supply chain faces a perfect storm of threats in the coming decades. From climate change to population growth, concerns over food scarcity are a worldwide issue. Damaging effects are likely to be seen first in the developing world, where a rapid shift towards urbanisation and an imbalance in supply and demand could …

The rise of sustainable food production Read More »

4 ways CellRev are revolutionising adherent cell culture

Leave a Comment / Blog / By Chris Green

Continuous processing is not new and is being adopted by more and more industries as they acknowledge the inherent limitations of batch processing. However, CellRev’s technology offers a revolutionary new approach to cell manufacturing. What is an adherent cell? There are two primary systems used for culturing cells: adherent cell culture and suspension cell culture. …

4 ways CellRev are revolutionising adherent cell culture Read More »

CellRev: From demand to development

Leave a Comment / Blog / By Josh Silver

CellRev has developed a revolutionary new approach to adherent cell culture, promising to transform the commercial potential of this nascent field. The company spun out of Newcastle University in 2019, where the foundations of its tech breakthrough first began. As a pioneering new company, CellRev’s innovation brings immense commercial potential, helping to match growing demand …

CellRev: From demand to development Read More »