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The Sticky Challenges of Bioprocessing

Cell-to-cell adhesion of mammalian cells is what cells are supposed to do, but can be quite detrimental to bioprocessing, upstream and downstream, by producing cell clumps with later formation of larger clusters. Single cell suspensions, microcarrier-adherent cells and stem cell aggregates demonstrate this behaviour. How do we prevent something natural from occurring? The typical workaround …

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Here’s why we are still “attached” to adherent cells

Except for hematopoietic-derived cells, most cells isolated from animals are naturally adherent. In vivo, adherent cells interact with their surrounding environment and with each other in order to remain viable and exercise their specific function. Indeed, the intracellular signalling cascades that influence the cells’ morphology, growth, phenotype and final fate are governed by the cells’ …

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A black and white image of mouse myoblasts on day three of a batch growth run.

From Spinner Flasks to Stirred Tanks: Challenges and Solutions for Cell Culture Scale Up

Multiple industries struggle to scale adherent cell culture for applications where the cells themselves are the target product. Traditional methods like T-flasks and multilayers, while useful in research settings, become limiting factors for large-scale production. Microcarrier-based cultures are a popular approach with many advantages, such as their high surface area per volume ratio, scalability, versatility, …

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The future of commercial-scale cell manufacturing

Cell culture is at the cutting edge of biological innovation. However, the need to reach commercial scale presents many practical, scientific, regulatory, and ideological challenges. In CellRev’s new trend report, ‘The Future of Commercial-Scale Cell Manufacturing’, we highlight the challenges and opportunities in the field – compiling insights from our industry-wide survey and interviews with …

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4 ways CellRev are revolutionising adherent cell culture

Continuous processing is not new and is being adopted by more and more industries as they acknowledge the inherent limitations of batch processing. However, CellRev’s technology offers a revolutionary new approach to cell manufacturing. What is an adherent cell? There are two primary systems used for culturing cells: adherent cell culture and suspension cell culture. …

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CellRev: From demand to development

CellRev has developed a revolutionary new approach to adherent cell culture, promising to transform the commercial potential of this nascent field. The company spun out of Newcastle University in 2019, where the foundations of its tech breakthrough first began. As a pioneering new company, CellRev’s innovation brings immense commercial potential, helping to match growing demand …

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