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Why upstream bioprocess inefficiencies are the Vaccine industry’s silent saboteur

Leave a Comment / Blog, Featured / By Chris Green

In the race to make vaccines faster, cheaper, and more equitably distributed, one challenge has quietly dragged behind the spotlight: upstream bioprocess inefficiencies. These early-stage production bottlenecks are where promising vaccine candidates either scale into commercial success or fizzle into sunk costs. And yet, despite their impact, upstream processes are often treated as rigid frameworks—something …

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Why tackling cell clumping could be the breakthrough the Vaccine industry needs

Leave a Comment / Blog / By Chris Green

In the shadow of pandemics, resurging viruses, and global vaccine inequality, the way we manufacture vaccines is more important than ever. Despite massive technological leaps in genetic sequencing, AI-assisted drug discovery, and cold-chain logistics, one fundamental aspect of vaccine production has stubbornly resisted progress: the way we grow the cells that produce them. At CellRev, …

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Enzyme-Powered Bioprocessing: A Three-Course Menu for Modern Manufacturing

Leave a Comment / Blog / By Chris Green

Enzymes are nature’s quiet overachievers, and at CellRev, we’re giving them a seat at the head of the bioprocessing table. This blog explores how our enzymes are transforming cell culture workflows from sticky messes to smooth, scalable systems. Here’s your three-course tasting menu. Starter: The Age-Old Alchemy of Enzymes From cheese to cell therapy, nature’s …

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AI-generated image of a white robotic hand against a blue-green background.

To automate or not to automate USP – what are the factors to consider?

Leave a Comment / Blog / By Kate Hannon

Within the bioprocessing industry it is often remarked that ‘the product is the process’; or rather, any change in the process, no matter how small, will impact the final product. Consequently, process consistency is seen as essential, and the automation of bioprocesses an appealing prospect as the industry matures. In particular, the automation of upstream …

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The Sticky Challenges of Bioprocessing

The Sticky Challenges of Bioprocessing

Leave a Comment / Blog, Featured / By Kate Hannon

Cell-to-cell adhesion of mammalian cells is what cells are supposed to do, but can be quite detrimental to bioprocessing, upstream and downstream, by producing cell clumps with later formation of larger clusters. Single cell suspensions, microcarrier-adherent cells and stem cell aggregates demonstrate this behaviour. How do we prevent something natural from occurring? The typical workaround …

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From Spinner Flasks to Stirred Tanks: Challenges and Solutions for Cell Culture Scale Up

From Spinner Flasks to Stirred Tanks: Challenges and Solutions for Cell Culture Scale Up

Leave a Comment / Blog / By Kate Hannon

Multiple industries struggle to scale adherent cell culture for applications where the cells themselves are the target product. Traditional methods like T-flasks and multilayers, while useful in research settings, become limiting factors for large-scale production. Microcarrier-based cultures are a popular approach with many advantages, such as their high surface area per volume ratio, scalability, versatility, …

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4 ways CellRev are revolutionising adherent cell culture

4 ways CellRev are revolutionising adherent cell culture

Leave a Comment / Blog / By Chris Green

Continuous processing is not new and is being adopted by more and more industries as they acknowledge the inherent limitations of batch processing. However, CellRev’s technology offers a revolutionary new approach to cell manufacturing. What is an adherent cell? There are two primary systems used for culturing cells: adherent cell culture and suspension cell culture. …

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CellRev: From demand to development

CellRev: From demand to development

Leave a Comment / Blog / By Josh Silver

CellRev has developed a revolutionary new approach to adherent cell culture, promising to transform the commercial potential of this nascent field. The company spun out of Newcastle University in 2019, where the foundations of its tech breakthrough first began. As a pioneering new company, CellRev’s innovation brings immense commercial potential, helping to match growing demand …

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