Kate Hannon, Author at CellRev

App Notes: AggreGuard & Kuraray Scapova CL PVA Microcarriers

Leave a Comment / Application Note / By Kate Hannon

We assess the impact of our media additive, AggreGuard, on cell-to-cell mediated microcarrier aggregation for VERO cells grown on Kuraray’s Scapova CL PVA microcarriers. Designed to increase cell viability and eliminate processing bottlenecks, AggreGuard controls and reduces cell-to-cell attachment without affecting cell-to-surface attachment. In this study, we put AggreGuard to the test to determine its …

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AI-generated image of a white robotic hand against a blue-green background.

To automate or not to automate USP – what are the factors to consider?

The Sticky Challenges of Bioprocessing

Leave a Comment / Blog, Featured / By Kate Hannon

Cell-to-cell adhesion of mammalian cells is what cells are supposed to do, but can be quite detrimental to bioprocessing, upstream and downstream, by producing cell clumps with later formation of larger clusters. Single cell suspensions, microcarrier-adherent cells and stem cell aggregates demonstrate this behaviour. How do we prevent something natural from occurring? The typical workaround …

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Here’s why we are still “attached” to adherent cells

Leave a Comment / Blog, Insights / By Kate Hannon

Except for hematopoietic-derived cells, most cells isolated from animals are naturally adherent. In vivo, adherent cells interact with their surrounding environment and with each other in order to remain viable and exercise their specific function. Indeed, the intracellular signalling cascades that influence the cells’ morphology, growth, phenotype and final fate are governed by the cells’ …

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From Spinner Flasks to Stirred Tanks: Challenges and Solutions for Cell Culture Scale Up

Leave a Comment / Blog, Insights / By Kate Hannon

Multiple industries struggle to scale adherent cell culture for applications where the cells themselves are the target product. Traditional methods like T-flasks and multilayers, while useful in research settings, become limiting factors for large-scale production. Microcarrier-based cultures are a popular approach with many advantages, such as their high surface area per volume ratio, scalability, versatility, …

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Author name: Kate Hannon