Author name: Kate Hannon

AI-generated image of a white robotic hand against a blue-green background.

To automate or not to automate USP – what are the factors to consider?

Within the bioprocessing industry it is often remarked that ‘the product is the process’; or rather, any change in the process, no matter how small, will impact the final product. Consequently, process consistency is seen as essential, and the automation of bioprocesses an appealing prospect as the industry matures. In particular, the automation of upstream …

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Process Development

The Sticky Challenges of Bioprocessing

Cell-to-cell adhesion of mammalian cells is what cells are supposed to do, but can be quite detrimental to bioprocessing, upstream and downstream, by producing cell clumps with later formation of larger clusters. Single cell suspensions, microcarrier-adherent cells and stem cell aggregates demonstrate this behaviour. How do we prevent something natural from occurring? The typical workaround …

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lab

Here’s why we are still “attached” to adherent cells

Except for hematopoietic-derived cells, most cells isolated from animals are naturally adherent. In vivo, adherent cells interact with their surrounding environment and with each other in order to remain viable and exercise their specific function. Indeed, the intracellular signalling cascades that influence the cells’ morphology, growth, phenotype and final fate are governed by the cells’ …

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A black and white image of mouse myoblasts on day three of a batch growth run.

From Spinner Flasks to Stirred Tanks: Challenges and Solutions for Cell Culture Scale Up

Multiple industries struggle to scale adherent cell culture for applications where the cells themselves are the target product. Traditional methods like T-flasks and multilayers, while useful in research settings, become limiting factors for large-scale production. Microcarrier-based cultures are a popular approach with many advantages, such as their high surface area per volume ratio, scalability, versatility, …

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Close up image of raw steak.

BSF Enterprise and CellRev to Form FoodTech Joint Venture

BSF Enterprise the Main Market listed biotech company and owner of pioneering UK-based tissue engineering company 3D Bio-Tissues (3DBT) and corneal tissue replacement company Kerato, has entered into a Terms Sheet for an exclusive Joint Venture with CellRev to help develop a new FoodTech company focused on developing, and offering to the market, an end …

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