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Here’s why we are still “attached” to adherent cells

Except for hematopoietic-derived cells, most cells isolated from animals are naturally adherent. In vivo, adherent cells interact with their surrounding environment and with each other in order to remain viable and exercise their specific function. Indeed, the intracellular signalling cascades that influence the cells’ morphology, growth, phenotype and final fate are governed by the cells’ …

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A black and white image of mouse myoblasts on day three of a batch growth run.

From Spinner Flasks to Stirred Tanks: Challenges and Solutions for Cell Culture Scale Up

Multiple industries struggle to scale adherent cell culture for applications where the cells themselves are the target product. Traditional methods like T-flasks and multilayers, while useful in research settings, become limiting factors for large-scale production. Microcarrier-based cultures are a popular approach with many advantages, such as their high surface area per volume ratio, scalability, versatility, …

From Spinner Flasks to Stirred Tanks: Challenges and Solutions for Cell Culture Scale Up Read More »