Author name: Chris Green

App Notes: AggreGuard & Kuraray Scapova AS used to culture human adipose-derived stem cells

Discover how our partner Kuraray Co. Ltd, achieved a 7-fold increase in cell count using a combination of Scapova™ AS PVA microcarriers and AggreGuard™. Designed to increase cell viability and eliminate processing bottlenecks, AggreGuard controls and reduces cell-to-cell adhesion without affecting cell-to-surface attachment. In this study, ADSCs were cultured in serum-free medium on iMatrix-511-coated SCAPOVA™ …

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Case Study: AggreGuard improves productivity, an eGFP model

AggreGuard™ facilitates reduced upstream process optimisation and increases eGFP-production post-transduction Cell-to-cell adhesion is the main driver of cell clumping and microcarrier aggregation in suspension-based agitated bioreactors.  CellRev tested a hypothesis: reducing cell-to-cell adhesion with AggreGuard™ in a representative upstream bioprocess can improve the viral titre while maintaining cell culture homogeneity without cell line engineering or …

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Poster: Advanced Therapies London 2025

Controlling cell-to-cell adhesion to facilitate process optimisation and intensification As presented by our Head of Technology at Advanced Therapies London in 2025, this poster provides an overview of the transformative benefits of AggreGuard on microcarrier-based cultures. Download Now

Case Study: Continuase empowering continuous processing

Continuase™: Empowering continuous cell manufacturing on multiple technology platforms for different scaling strategies In this case study CellRev demonstrates how Continuase™, a proprietary media additive, is capable of controlling cell-to-surface attachment. Continuase™ was used to develop a first of its kind continuous biomanufacturing process on different bioreactors to showcase clear techno-economic advantages for the emerging …

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Poster: ESACT UK 2025

AggreGuard: Transforming process efficiency one supplement at a time. As presented by our Head of Technology at ESACT UK in 2025, this poster provides an overview of the transformative effects of AggreGuard on microcarrier-based cultures. Download Now

The future of commercial-scale cell manufacturing

The future of commercial-scale cell manufacturing

Cell culture is at the cutting edge of biological innovation. However, the need to reach commercial scale presents many practical, scientific, regulatory, and ideological challenges. In CellRev’s new trend report, ‘The Future of Commercial-Scale Cell Manufacturing’, we highlight the challenges and opportunities in the field – compiling insights from our industry-wide survey and interviews with …

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4 ways CellRev are revolutionising adherent cell culture

4 ways CellRev are revolutionising adherent cell culture

Continuous processing is not new and is being adopted by more and more industries as they acknowledge the inherent limitations of batch processing. However, CellRev’s technology offers a revolutionary new approach to cell manufacturing. What is an adherent cell? There are two primary systems used for culturing cells: adherent cell culture and suspension cell culture. …

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