Case Study

AggreGuard™ facilitates reduced upstream process optimisation and increases eGFP-production post-transduction Cell-to-cell adhesion is the main driver of cell clumping and microcarrier aggregation in suspension-based agitated bioreactors.  CellRev tested a hypothesis: reducing cell-to-cell adhesion with AggreGuard™ in a representative upstream bioprocess can improve the viral titre while maintaining cell culture homogeneity without cell line engineering or …

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AggreGuard™: VERO cells case study The reported findings highlight the potential to improve VERO upstream bioprocessing efficiency for existing batch/fed-batch modes using AggreGuard™. Experimental design considerations: Cell type and microcarrier (MC) selection screens (if data is unknown). AggreGuard™ time-dose response screening in multi-well plates to evaluate cell type (i.e., extracellular matrix composition, attachment behaviour, doubling …

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